Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ TRPC3 Channel Inhibitor III, Pyr10
A cell-permeable pyrazole derivative that acts as a selective blocker of the transient receptor potential cation channel TRPC3-medated ROCE (receptor-operated Ca2+ entry) and inhibits Carbachol- (
MilliporeSigma™ Calbiochem™ TTNPB
A synthetic stilbene analog of retinoic acid that acts as a potent retinoic acid receptor (RAR) agonist (EC50 = 21 nM, 4.0 nM, and 2.4nM for RARα, RARβ, and RARγ, respectively).
MilliporeSigma™ Calbiochem™ U0124
A useful negative control for MEK inhibitors U0125 and U0126.
MilliporeSigma™ Calbiochem™ InSolution™ AG 1478
Highly potent and specific inhibitor of the epidermal growth factor (EGF) receptor tyrosine kinase (IC50 = 3nM)
MilliporeSigma™ Calbiochem™ DUB Inhibitor VI, P22077
The DUB Inhibitor VI, P22077 controls the biological activity of DUB. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
MilliporeSigma™ Calbiochem™ Iron Chelator IV, 21H7
The Iron Chelator IV, 21H7 controls the biological activity of iron-regulated enzymes. This small molecule/inhibitor is primarily used for Cancer applications.
MilliporeSigma™ Calbiochem™ Xestospongin C, Xestospongia sp.
An oxaquinolizidine alkaloid isolated from a marine sponge.
MilliporeSigma™ Calbiochem™ VEGFR Tyrosine Kinase Inhibitor VI, AAL-993
The VEGFR Tyrosine Kinse Inhibitor VI, ALL-993, also referenced under CAS 269390-77-4, controls the biological activity of VEGFR Tyrosine Kinase. This small molecule/inhibitor is primarily used for Cancer applications.
MilliporeSigma™ Calbiochem™ Wnt Pathway Inhibitor XI, CCT036477
The Wnt Pathway Inhibitor XI, CCT036477, also referenced under CAS 305372-78-5, controls the biological activity of Wnt Pathway. This small molecule/inhibitor is primarily used for Cancer applications.
MilliporeSigma™ Calbiochem™ Wnt Antagonist I, IWR-1-endo
Wnt Antagonist I, IWR-1-endo, is a cell-permeable inhibitor of TNKS1/PARP5a (IC50 = 131 nM) & TNKS2/PARP5b (IC50≥ 56 nM). Suppress Wnt-stimulated transcription activity (IC50 = 180 nM).
MilliporeSigma™ Calbiochem™ Wortmannin
Wortmannin, CAS 19545-26-7, is a cell-permeable, potent, selective, and irreversible inhibitor of PI3-Kinase (IC50 = 5 nM). Does not affect any upstream signaling events.
MilliporeSigma™ Calbiochem™ Sodium Orthovanadate, Activated
A depolymerized vanadate prepared from Sodium Orthovanadate with enhanced ability to competitively inhibit endogenous phosphatases.
MilliporeSigma™ Calbiochem™ Methotrexate
Inhibits thymidylate synthetase, is a nonselective de novo purine synthesis inhibitor, and has a significant toxicity profile including hepatotoxicity, pneumonitis, and bone marrow suppress
MilliporeSigma™ Calbiochem™ InSolution™ MG-132
InSolution™ MG-132, CAS 133407-82-6, is provided as a 10 mM solution in DMSO. Acts as a potent, reversible proteasome inhibitor (Ki = 4 nM).
MilliporeSigma™ Calbiochem™ Mifepristone
A cell-permeable synthetic steroid that acts as a potent antagonist of progesterone and glucocorticoid receptors.